Cobalamin-Dependent Apparent Intramolecular Methyl Transfer for Biocatalytic Constitutional Isomerization of Catechol Monomethyl Ethers
نویسندگان
چکیده
منابع مشابه
Computational modeling of methyl transfer reactions catalyzed by cobalamin-dependent methionine synthase enzyme
The cobalamin-dependent methionine synthase enzyme (MetH) catalyzes the transfer of the methyl group from methyltetrahydrofolate (CH3-H4folate) to homocysteine (Hcy) thus forming methionine (Met). The key step in the catalytic cycle involves displacement of the methyl group from the methylcobalamin cofactor (MeCbl) to Hcy in which the cobalamin cofactor serves as an intermediate cycling between...
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This work was presented in part at the meeting ofthe American Society of Human Genetics, San Diego, Calif., October 1977. Dr. Mellman and Dr. Willard are recipients of traineeships from the National Institutes of Health (T01-GM 02299). Dr. Mellman's present address is Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York 10021. Received for publication 18 May 19...
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Cobalamin-dependent methionine synthase catalyzes the transfer of a methyl group from N5-methyltetrahydrofolate to homocysteine, producing tetrahydrofolate and methionine. Insufficient availability of cobalamin, or inhibition of methionine synthase by exposure to nitrous oxide, leads to diminished activity of this enzyme. In humans, severe inhibition of methionine synthase results in the develo...
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ژورنال
عنوان ژورنال: ACS Catalysis
سال: 2019
ISSN: 2155-5435,2155-5435
DOI: 10.1021/acscatal.8b05072